Protein Z Deficiency in Antiphospholipid-Negative Sneddon’s Syndrome
نویسندگان
چکیده
منابع مشابه
Protein Z deficiency in antiphospholipid-negative Sneddon's syndrome.
BACKGROUND Sneddon's syndrome is characterized by the association of ischemic cerebrovascular events and widespread livedo racemosa. The pathophysiology of Sneddon's syndrome remains elusive, but various prothrombotic abnormalities have been previously reported in this setting. Low levels of protein Z, a downregulator of coagulation, have been recently linked to an increased risk of arterial th...
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Protein Z (PZ) is a plasma vitamin K-dependent protein that functions as a cofactor to dramatically enhance the inhibition of coagulation factor Xa by the serpin, protein Z-dependent protease inhibitor (ZPI). In vitro, ZPI not only inhibits factor Xa in a calcium ion-, phospholipid-, and PZ-dependent fashion, but also directly inhibits coagulation factor XIa. In murine gene-deletion models, PZ ...
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Protein Z (PZ) is a vitamin K-dependent plasma protein whose function has been uncertain. The structure of PZ is very similar to that of the coagulation-related factors VII, IX, and X and PC, but PZ differs from these other proteins in that it is not the zymogen of a serine protease. We have shown recently that PZ forms a calcium ion-dependent complex with activated factor X at phospholipid sur...
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North Am 2000;26:215–27. 14 Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull 1997;53:491–508. 15 Elkon KB. Apoptosis in SLE – too little or too much? Review. Clin Exp Rheumatol 1994;12:553–9. 16 Drappa J, Vaishnaw AK, Sullivan KE, Chu JL, Elkon KB. Fas gene-mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmu...
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ژورنال
عنوان ژورنال: Stroke
سال: 2004
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000127534.54538.15